What is Daclatasvir 60mg (Daklinza)?
Daclatasvir 60mg (Daklinza) is an oral tablet used for the treatment of chronic infection with the hepatitis C virus (HCV), genotype 1 or 3.
Daclatasvir 60mg (Daklinza) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body.
Daclatasvir 60mg (Daklinza) belongs to a class of drugs called direct-acting antiviral agents (DAAs).
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Each green, biconvex, pentagonal tablet, debossed with “BMS” on one side and “213” on the other, contains 30 mg of daclatasvir. Nonmedicinal ingredients: anhydrous lactose, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, silicon dioxide, and Opadry Green (FD&C Blue No. 2 / indigo carmine aluminum lake, hypromellose, iron oxide (yellow), polyethylene glycol 400, and titanium dioxide).
Each light green, biconvex, pentagonal tablet, debossed with “BMS” on one side and “215” on the other, contains 60 mg of daclatasvir. Nonmedicinal ingredients: anhydrous lactose, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, silicon dioxide and Opadry Green (FD&C Blue No. 2 / indigo carmine aluminum lake, hypromellose, iron oxide (yellow), polyethylene glycol 400, and titanium dioxide).
How to use?
The recommended dose of daclatasvir is 60 mg once daily with or without food for 12 weeks.
Daclatasvir is used in combination with sofosbuvir.
The dose should be reduced to 30 mg once daily when drugs that block the breakdown of daclatasvir are being used.
The dose should be increased to 90 mg once daily when drugs that increase the breakdown of daclatasvir are being used.
If you miss a dose, and remember less than 20 hours after the scheduled dose, take it as soon as possible and continue with your regular schedule. If it is less than 4 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Store this medication at room temperature in the original container. Protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage.
Common side effects include:
Anemia (when combined with ribavirin)
Other side effects include:
Serious side effects include:
Severe reduction in heart rate (bradycardia) has occurred in people who were treated with daclatasvir and sofosbuvir while also being treated with amiodarone (Cordarone).
Daclatasvir may cause reactivation of hepatitis B virus (HBV) in people who are infected with HBV and HCV.
Other viral infections: The safety and effectiveness of using this medication to treat hepatitis C infection when you have hepatitis B infection or human immunodeficiency virus (HIV) have not been determined. The use of daclatasvir when you have infection caused by either of these two viruses is not recommended.
Which drugs or supplements interact with daclatasvir (Daklinza)?
Daclatasvir has many drug interactions.
Rifampin, carbamazepine, phenytoin, and St. John’s wort may reduce blood levels of daclatasvir and reduce its effectiveness by increasing its metabolism (break-down) in the intestine. Therefore, daclatasvir should not be combined with rifampin, carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol), phenytoin (Dilantin, Dilantin-125), or St. John’s wort.
Other drugs that also may reduce blood levels of Daclatasvir include:
Drugs that increase blood levels of daclatasvir by reducing its break down in the liver include:
atazanavir (Reyataz) with ritonavir (Norvir)
Daclatasvir increases blood levels of
rosuvastatin (Crestor), and
Side effects of statins such as muscle pain should be monitored.
Daclatasvir also increases blood levels of buprenorphine (Buprenex, Subutex) and digoxin.